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Intracytoplasmic sperm injection (ICSI)

Intracytoplasmic sperm injection (ICSI) is a procedure used in conjunction with in vitro fertilization. It is indicated in couples with male factor subfertility or previous failed fertilisation with standard IVF. In couples with no sperm in the ejaculate, sperm is retrieved directly from the vas deferens or testes (Surgical sperm retrieval) to be used for ICSI.

Intracytoplasmic sperm injection (ICSI) | Birmingham Fertility CentreICSI involves an additional step in the laboratory. Following egg collection, sperm sample is prepared in the laboratory. Using special microscopes, a single sperm is injected directly into each mature egg. Following  fertilization, the embryo will be transferred into the uterus as in standard IVF treatment

Surgical Sperm retrieval :  This may be percutaneous epididymal sperm aspiration (PESA) or testicular sperm extraction (TESE), or open testicular biopsy.  These procedures allow the sperm to be extracted directly from a man’s epididymis or testicle. The procedures may be done under a local anesthesia or general anesthetic.  An open testicular biopsy is usually done under a general anesthetic.

In some cases, sperm may not be retrieved and use of donor sperm may be discussed before treatment is commenced.

The pregnancy rates with ICSI are similar to those of IVF treatment and the age of the female partner is a significant factor determining success of treatment.